The combination therapy: when efficiency and safety go an arm about arm

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Aim: To evaluate efficacy and tolerance of a compound drug Co-renitec combining an ACE inhibitor enalapril maleate and diuretic
hydrochlorothiazide. Co-renitec taken for 16 weeks in patients with essential hypertension (EH). Material and methods: 28 patients
with EH (16 males and 12 females aged 47-74 years) of mean duration 132 years. Blood pressure (BP) was monitored for 24 hours
with the device SL 90207 (SpaceLabs Medical, USA). Microalbuminuria (MAU) was estimated with the use of immunoturbodimetric
test. Results: By 24-hour monitoring, Co-renitec reduced day BP by 15/9 - 3/2 mm Hg, nocturnal BP lowered by 19/12 - 3/2 mmHg,
pulse pressure also fell. Coefficient T/P was 53% for systolic BP (SBP) and 60% for diastolic BP (DBP). The target BP was reached in
70% patients. Co-renitec significantly decreased MAU, albumines excretion normalized in 46% patients. Conclusion: Co-renitec lowers
both day and nocturnal blood pressure, improves 24-h rhythm of BP, has a positive effect on the kidneys. This allows its recommendation
as a first-line drug in patients with moderate and severe EH.

About the authors

I E Chazova

L G Ratova


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